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Updated: Aug 11, 2026

A Patient-Derived Xenograft Model for Venous Malformation
Published on: June 15, 2020
[Hyperkeratotic vascular malformations. Presentation of three cases]
Enric Piqué1, Juan A Pérez-Cejudo, Santiago Palacios
1Sección de Dermatología, Hospital General de Lanzarote, Las Palmas, Spain. epique@medynet.com
Abstract:
Hyperkeratotic vascular malformations (verrucous hemangiomas) are infrequent vascular lesions present from birth. Initially, they are reminiscent of port wine stains or childhood hemangioma, but over time they gradually take on their typical warty and hyperkeratotic appearance. These changes are probably due to trauma, scratching and bleeding episodes. Because the lesion is deep and goes beyond the clinical lesion, treatment is difficult and involves many recurrences. We present three cases of this vascular malformation, in two males aged 45 and 62 and a 30-year-old female. All three had the lesion from birth, and presented with frequent bleeding episodes.
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