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[Acneiform eruption secondary to cetuximab]
Enrique Herrera-Acosta1, Gemma Martín-Ezquerra, Maribel Iglesias
1Departamento de Dermatología, Hospital Universitario Sagrat Cor, Paris 83-87, 5o. piso, 08029 Barcelona, Spain. ireuaumu@retemail.es
Actas Dermo-Sifiliograficas
|February 16, 2006
Summary
Cetuximab, a cancer drug, can cause acne-like skin rashes in patients. This side effect, an acneiform eruption, often appears on the face and upper body, requiring management during treatment.
Area of Science:
- Oncology
- Dermatology
- Pharmacology
Background:
- Cetuximab (C225) is a monoclonal antibody targeting the epidermal growth factor receptor (EGF-R).
- It is utilized in treating advanced solid malignant tumors by inhibiting proliferation, angiogenesis, metastasis, and promoting apoptosis.
Observation:
- A 64-year-old male patient with colon neoplasm and hepatic metastases developed a facial and truncal papulopustular skin eruption.
- Biopsy confirmed an acneiform eruption, a known side effect of cetuximab treatment.
Findings:
- The patient's acneiform eruption responded favorably to minocycline treatment.
- Recurrence of the eruption, albeit less severe, was noted upon subsequent cetuximab administration.
Implications:
- Acneiform eruptions are a frequent adverse effect of cetuximab therapy.
- Cetuximab should be recognized as a potential cause of drug-induced acneiform eruptions in clinical practice.