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[Bullous pemphigoid in an infant after vaccination]

Carolina Mérida1, Jorge A Martínez-Escribano, José F Frías

  • 1Sección de Alergología, Hospital Universitario Virgen de la Arrixaca, Ctra. Madrid-Cartagena, 30120 El Palmar, Murcia, Spain. jmescribano@huva.es

Actas Dermo-Sifiliograficas
|February 16, 2006
PubMed

Insights

Bullous pemphigoid (BP) in infants is rare. This case study details a two-month-old infant who developed BP lesions after vaccinations, which resolved with treatment.

Area of Science:

  • Pediatric Dermatology
  • Immunology

Background:

  • Bullous pemphigoid (BP) typically affects the elderly.
  • Infantile BP is uncommon, with limited case reports.

Observation:

  • A two-month-old infant presented with bullous lesions on palms and soles.
  • Lesions appeared after the first dose of hepatitis B, polio, DTP, and HiB vaccines.
  • A second, more generalized outbreak occurred after the second vaccine dose.

Findings:

  • The infant's BP resolved with topical and systemic corticosteroid treatment (deflazacort).
  • The patient remained lesion-free for five years post-vaccination and subsequent treatment.
  • No recurrence of BP was observed despite completion of the standard vaccination schedule.

Implications:

  • This case suggests a potential, though rare, association between certain childhood vaccinations and the onset of bullous pemphigoid.
  • Early diagnosis and appropriate treatment are crucial for managing infantile BP.
  • Further research may be warranted to explore the immunological mechanisms linking vaccines and BP in infants.

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