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Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay
Published on: June 25, 2019
[Idiopathic atrophoderma of Pasini and Pierini. Study of 4 cases]
Alfonso González-Morán1, Rocío Martín-López, María L Ramos
1Sección de Dermatología, Hospital Nuestra Señora de Sonsoles, Castilla 1, 1.o-1.a, 05005 Avila, Spain. agonzalezm@medynet.com
Abstract:
Idiopathic atrophoderma of Pasini and Pierini (IAPP) is an infrequent form of cutaneous atrophy, of unknown etiology. We describe the clinical and histological symptoms of four women with IAPP. Three of them had lesions on the back, while the fourth had them on the buttocks. The histological study of two patients revealed a variable degree of collagen alteration (sclerosis and hyalinization). In the other patients, the dermis was apparently normal. There is discussion about whether IAPP is a distinct entity or is related to morphea. Both sets of symptoms, although separate, could form part of the same spectrum within the fibrosing type of dermatoses. We found no positive serology for B. burgdorferi in our patients.