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Updated: Aug 11, 2026

Growth, Purification, and Titration of Oncolytic Herpes Simplex Virus
Published on: May 13, 2021
A tale of 2 alpha-herpesviruses: lessons for vaccinologists
Barry T Rouse1, Shilpa Deshpande Kaistha
1Department of Microbiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA. btr@utk.edu
Abstract:
Of the 8 known herpesviruses that affect human beings, we only have successful vaccines against varicella zoster virus. This brief review compares the pathogenesis of varicella zoster virus with that of the closely related alpha-herpesviruses herpes simplex virus 1 and 2, for which we have no satisfactory vaccines. The main objective of this review is to learn lessons from the success of varicella zoster virus vaccine that could be exploited for the development of successful vaccines against herpes simplex virus and perhaps against other herpes viruses.
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