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Primary intrathoracic biphasic synovial sarcoma--a case report
Bolesław Papla1, Maria Harazda, Jarosław Kuzdzał
1Department of Clinical and Experimental Pathomorphology, Collegium Medicum, Jagiellonian University, Kraków.
Summary
This report details a rare synovial sarcoma case affecting both pleural cavities in a 66-year-old woman. The diagnosis was confirmed using fluorescence in situ hybridization (FISH) to detect the characteristic t(X;18) translocation.
Area of Science:
- Oncology
- Pathology
- Medical Genetics
Background:
- Synovial sarcoma is a rare malignant soft tissue tumor.
- Biphasic synovial sarcoma typically affects the extremities but can occur in the pleura.
- Pleural sarcomas are exceptionally rare, with synovial sarcoma being an even rarer subtype in this location.
Observation:
- A 66-year-old woman presented with a rare case of synovial sarcoma.
- The tumor involved both pleural cavities, a highly unusual presentation.
- Diagnostic imaging revealed bilateral pleural masses.
Findings:
- Histopathological examination confirmed synovial sarcoma.
- Fluorescence in situ hybridization (FISH) detected the specific t(X;18) chromosomal translocation.
- This translocation is a hallmark genetic alteration in synovial sarcoma.
Implications:
- This case highlights the importance of considering rare diagnoses in challenging presentations.
- Accurate genetic confirmation (t(X;18) via FISH) is crucial for diagnosing synovial sarcoma.
- Understanding rare presentations aids in developing targeted diagnostic and therapeutic strategies for pleural malignancies.