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Updated: Jul 16, 2026

Design and Synthesis of a Reconfigurable DNA Accordion Rack
Published on: August 15, 2018
Rewritable DNA microarrays
W C E Schofield1, J McGettrick, T J Bradley
1Department of Chemistry, Science Laboratories, and School of Biological and Biomedical Science, Durham University, Durham DH1 3LE, England, UK.
Abstract:
Thiol-terminated single-stranded deoxyribonucleic acids (ssDNA) can be immobilized onto pulsed plasma deposited poly(allylmercaptan) surfaces via disulfide bridge chemistry and are found to readily undergo nucleic acid hybridization. Unlike other methods for oligonucleotide attachment to solid surfaces, this approach is shown to be independent of substrate material or geometry, and amenable to highly efficient rewriting.
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