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Zebrafish transgenic Enhancer TRAP line database (ZETRAP).

Benjamin G H Choo1, Igor Kondrichin, Sergey Parinov

  • 1Institute of Molecular and Cell Biology, 61 Biopolis Dr, Proteos, 138673, Singapore. benjaminchoogh@yahoo.com

BMC Developmental Biology
|February 16, 2006
PubMed
Summary

Zebrafish enhancer trap (ET) lines generated using Tol2 transposon technology are cataloged in the Zebrafish Enhancer TRAP lines database (ZETRAP). This resource aids research into vertebrate development and genetics.

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Area of Science:

  • Developmental Biology
  • Genetics
  • Transgenesis

Background:

  • Zebrafish (Danio rerio) are a key model organism for studying vertebrate genetics and development.
  • Enhancer trap (ET) technology using the Tol2 transposon offers a method for high-resolution, real-time studies of vertebrate embryogenesis.

Purpose of the Study:

  • To compile and present data on ET transgenic zebrafish lines.
  • To create a centralized, accessible resource for researchers.

Main Methods:

  • Systematic investigation and data collection from multiple ET transgenic zebrafish lines.
  • Development of an online database, the Zebrafish Enhancer TRAP lines database (ZETRAP).

Main Results:

  • ZETRAP (version 1.0) is a web-based system detailing 27 ET lines.

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  • These lines express enhanced green fluorescent protein (EGFP) in various organs and tissues (e.g., heart, brain, notochord, gut).
  • Insertion sites of the Tol2 transposon are documented for each line.

    • Conclusions:

    • ZETRAP provides valuable data on the developmental, genetic, and genomic aspects of Tol2 transposon-mediated transgenic zebrafish.
    • The database serves the scientific community by facilitating research on these valuable transgenic models.