Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hydroxyurea induced perimalleolar ulcers.

Kavitha Saravu1, Praveen Velappan, Naik Lakshmi

  • 1Department of Medicine, Kasturba Medical College, Manipal, India. kavithasaravu@yahoo.com

Journal of Korean Medical Science
|February 16, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Leptospirosis and its co-infections in India: prevalence, geographic distribution, and clinical implications.

BMC infectious diseases·2026
Same author

Leptospirosis is associated with severity, increased resource utilization, and mortality among acute febrile illnesses from Karnataka, Southwestern India.

Annals of medicine·2026
Same author

Epidemiology and Outcomes of Burn Injuries: A Retrospective Study at a Tertiary Care Center.

Annals of plastic surgery·2026
Same author

Predictive utility of the baseline Tp-e interval for early arrhythmic events in acute myocardial infarction: A cohort study.

The Journal of international medical research·2026
Same author

Impact of patient care interventions on clinical, humanistic, and treatment outcomes of tuberculosis patients with diabetes mellitus: A systematic review.

Exploratory research in clinical and social pharmacy·2026
Same author

Platelet Drp1 phosphorylation provides a platform for immune-based platelet function testing.

Blood·2026
Same journal

EGFR and Its Ligands in Idiopathic Pulmonary Fibrosis: Predicting Clinical Outcomes and Molecular Endotyping Through In-Depth Analysis.

Journal of Korean medical science·2026
Same journal

<i>APOE</i> Genotype Modifies the Predictive Performance of Plasma Biomarkers for Amyloid Plaque Burden in Subjective Cognitive Decline.

Journal of Korean medical science·2026
Same journal

Two-Year Outcomes of a Randomized Controlled Trial of Nonintervention Versus Oral Ibuprofen for Patent Ductus Arteriosus in Premature Infants.

Journal of Korean medical science·2026
Same journal

Technology-Dependent Children Living at Home in Korea: A Population-Based Analysis Using NHIS Claims Data.

Journal of Korean medical science·2026
Same journal

Retracted Publications Related to Statistics: A Scopus-Based Bibliometric Analysis.

Journal of Korean medical science·2026
Same journal

Tuberculosis Development in Chronic Obstructive Pulmonary Disease: A Nationwide Population-Based Study.

Journal of Korean medical science·2026
See all related articles

Hydroxyurea (HU) can cause rare leg ulcers in patients with myeloproliferative disorders. Stopping HU treatment effectively healed these painful ulcers in all reported cases.

Area of Science:

  • Dermatology
  • Hematology
  • Oncology

Background:

  • Hydroxyurea (HU) is a vital antineoplastic agent for myeloproliferative disorders.
  • Dermatological side effects of HU are common, but leg ulcers are rare.
  • Early recognition of HU-induced leg ulcers is crucial for timely intervention.

Observation:

  • Four cases of leg ulcers associated with chronic hydroxyurea therapy are presented.
  • Patients with chronic myeloid leukemia and polycythemia vera developed perimalleolar ulcers.
  • Ulcers varied in location (perimalleolar, lateral malleolar, medial malleolar) and duration.

Findings:

  • All four patients experienced painful leg ulcers linked to hydroxyurea use.
  • Ulcer healing was consistently observed upon discontinuation of hydroxyurea.

Related Experiment Videos

  • The severity of ulcers did not always correlate with HU dosage or duration.

    • Implications:

    • This report highlights the association between chronic hydroxyurea therapy and perimalleolar leg ulcers.
    • Increased physician awareness can lead to earlier diagnosis and effective management of these ulcers.
    • Promptly stopping hydroxyurea offers a successful treatment strategy for these debilitating ulcers.