Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Is it easy to stop RNA polymerase?

Irina Artsimovitch1, Dmitry G Vassylyev

  • 1Department of Microbiology, The Ohio State University, Columbus, Ohio, USA.

Cell Cycle (Georgetown, Tex.)
|February 16, 2006
PubMed
Summary

New rifamycin derivatives show promise as antibacterial agents by targeting bacterial RNA polymerase (RNAP). Understanding RNAP-rifamycin complexes aids in designing drugs to overcome bacterial resistance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Copy-back RNA synthesis by coronavirus polymerase requires helicase activity and is stimulated by remdesivir and molnupiravir.

Science advances·2026
Same author

Selective targeting of a histone-like silencer Sfx to the R6K conjugal transfer operon.

Nucleic acids research·2026
Same author

The ω subunit stabilizes transcribing RNA polymerase to balance processivity and collision resolution.

bioRxiv : the preprint server for biology·2026
Same author

Exploration of the structural and functional diversity in the metamorphic RfaH subfamily.

bioRxiv : the preprint server for biology·2026
Same author

Selective targeting of a histone-like silencer Sfx to the R6K conjugal transfer operon.

bioRxiv : the preprint server for biology·2026
Same author

Template switching by coronavirus polymerase requires helicase activity and is stimulated by remdesivir and molnupiravir.

bioRxiv : the preprint server for biology·2025

Area of Science:

  • Microbiology
  • Molecular Biology
  • Drug Discovery

Background:

  • Bacterial RNA polymerase (RNAP) is a key target for antibacterial agents.
  • Rifamycins are clinically used RNAP inhibitors but face bacterial resistance.
  • Developing novel inhibitors requires understanding RNAP-bacterial interactions.

Purpose of the Study:

  • To review recent advances in understanding prokaryotic transcription.
  • To explore structural and functional characterization of RNAP/rifamycin complexes.
  • To identify opportunities for designing improved antibacterial agents.

Main Methods:

  • Review of recent literature on prokaryotic transcription.
  • Analysis of structural and functional data of RNAP/rifamycin complexes.
  • Focus on mechanisms of inhibition and resistance.

Main Results:

  • Detailed structural and functional insights into RNAP/rifamycin interactions.
  • Identification of key features for broad-spectrum activity and reduced host toxicity.
  • Understanding of mechanisms contributing to bacterial resistance.

Conclusions:

  • Advances in structural biology offer new avenues for antibiotic design.
  • Targeting bacterial RNAP with novel rifamycin derivatives can overcome resistance.
  • Future drug development can lead to more effective antibacterial therapies.

Related Experiment Videos