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Related Experiment Videos

Sources of tissue factor.

Bjarne Østerud1, Eirik Bjørklid

  • 1Department of Biochemistry, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, Tromsø, Norway. Bjarne.Osterud@fagmed.uit.no

Seminars in Thrombosis and Hemostasis
|February 16, 2006
PubMed
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Tissue factor (TF) is found in various tissues and cell types, with its role extending beyond hemostasis to include blood-borne activity. Platelets may help activate TF from monocytes.

Area of Science:

  • Biochemistry
  • Hematology
  • Cell Biology

Background:

  • Tissue factor (TF) displays a non-uniform distribution across human tissues.
  • Constitutive TF expression occurs in cells like astrocytes, epithelial cells, fibroblasts, pericytes, and myocytes.
  • TF levels increase upon activation in smooth muscle cells, monocytes, and macrophages.

Purpose of the Study:

  • To explore the distribution and cellular expression of Tissue Factor (TF).
  • To investigate the role of TF beyond its traditional hemostatic function.
  • To examine the contribution of blood-borne TF and its interaction with platelets.

Main Methods:

  • Review of existing literature on TF distribution and expression.
  • Analysis of studies investigating TF activity in blood under various conditions.

Related Experiment Videos

  • Examination of TF presence in microparticles and soluble forms in plasma.

    • Main Results:

    • TF is highly expressed in vascularized organs like the lung, brain, and placenta.
    • Blood-borne TF activity, particularly under shear stress and with activated platelets, challenges the hemostatic envelope concept.
    • TF activity in plasma involves microparticles, soluble spliced variants, and potentially platelet-mediated decryption of monocyte TF.

    Conclusions:

    • TF's role is multifaceted, extending beyond local hemostasis to systemic circulation.
    • Blood-borne TF, influenced by shear stress and platelets, is significant.
    • Platelets may play a crucial role in activating TF derived from monocytes.