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Emerging insights in tissue factor-dependent signaling events
Henri H Versteeg1, Wolfram Ruf
1Department of Immunology, The Scripps Institute, La Jolla, CA 92037, USA. versteeg@scripps.edu
Seminars in Thrombosis and Hemostasis
|February 16, 2006
Summary
Tissue factor (TF) and factor VIIa initiate blood clotting and also regulate inflammation, tumor growth, and angiogenesis through cell signaling pathways. This review explores TF
Area of Science:
- Biochemistry
- Cell Biology
- Physiology
Background:
- The tissue factor (TF)-factor VIIa (FVIIa) complex initiates the coagulation cascade.
- Emerging evidence highlights TF's significant nonhemostatic roles beyond coagulation.
Purpose of the Study:
- To review the direct cell signaling pathways of TF.
- To elucidate the emerging roles of TF in (patho)physiology.
Main Methods:
- Literature review of TF signaling pathways.
- Analysis of TF's involvement in nonhemostatic functions.
Main Results:
- TF-FVIIa complex activates protease-activated receptor 2 (PAR2).
- TF signaling regulates gene transcription, cell proliferation, survival, motility, and integrin activation.
- TF plays critical roles in inflammation, tumor growth, and angiogenesis.
Conclusions:
- TF is a key mediator in both hemostasis and nonhemostatic processes.
- Understanding TF's direct signaling is crucial for its role in disease pathophysiology.