Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tissue factor in trauma and organ dysfunction.

Satoshi Gando1

  • 1Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan. gando@med.hokudai.ac.jp

Seminars in Thrombosis and Hemostasis
|February 16, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disseminated intravascular coagulation, clarity of existing terminology… or more confusion?

Journal of thrombosis and haemostasis : JTH·2026
Same author

Disseminated intravascular coagulation resolution as a surrogate outcome for mortality in sepsis-associated disseminated intravascular coagulation.

Thrombosis research·2025
Same author

Erratum: Utility of Sepsis-induced Coagulopathy among Disseminated Intravascular Coagulation Diagnostic Criteria: A Multicenter Retrospective Validation Study.

Thrombosis and haemostasis·2025
Same author

Correction: Clinical practice guidelines for management of disseminated intravascular coagulation in Japan 2024: part 4-trauma, burn, obstetrics, acute pancreatitis/liver failure, and others.

International journal of hematology·2025
Same author

Carbapenem Usage in the Initial Antibiotic Therapy of Sepsis in Japanese Intensive Care Units.

Cureus·2025
Same author

Utility of Sepsis-induced Coagulopathy Among Disseminated Intravascular Coagulation Diagnostic Criteria: A Multicenter Retrospective Validation Study.

Thrombosis and haemostasis·2025

Tissue factor (TF) is crucial for blood clotting and wound repair. In trauma, TF contributes to organ dysfunction, thrombosis, and inflammation, especially in patients with disseminated intravascular coagulation (DIC).

Area of Science:

  • Hematology
  • Trauma Pathophysiology
  • Coagulation Biology

Background:

  • Tissue factor (TF) initiates the extrinsic coagulation pathway, essential for hemostasis and wound repair.
  • TF also contributes to organ dysfunction in trauma by promoting thrombosis and inflammation.
  • Elevated TF levels in trauma patients, particularly those with DIC, are linked to systemic inflammation.

Purpose of the Study:

  • To elucidate the role of tissue factor in post-trauma organ dysfunction.
  • To investigate the interplay between TF, coagulation, and inflammation in trauma patients.
  • To understand the mechanisms underlying TF-mediated pathology in disseminated intravascular coagulation (DIC).

Main Methods:

  • Analysis of TF expression and levels in trauma patient plasma.

Related Experiment Videos

  • Assessment of coagulation activation markers.
  • Evaluation of inflammatory markers and systemic inflammatory response syndrome (SIRS).
  • Correlation of TF levels with DIC and multiple organ dysfunction syndrome (MODS) development.

    • Main Results:

    • Trauma leads to the release of constitutive TF and inducible TF expression, increasing plasma TF levels.
    • Marked TF generation in post-trauma DIC is often inadequately regulated by inhibitors like tissue factor pathway inhibitor (TFPI).
    • Synergistic activation of TF-dependent coagulation and inflammation contributes to MODS pathogenesis.

    Conclusions:

    • Tissue factor plays a critical role in the pathological processes following trauma, including thrombosis and inflammation.
    • Dysregulated TF activity, coupled with inflammation, is a key driver of post-trauma DIC and MODS.
    • Understanding TF's role is vital for developing therapeutic strategies for trauma-induced organ dysfunction.