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(Re)defining stem cells.

Stanley Shostak1

  • 1Department of Biological Sciences, University of Pittsburgh, PA 15260, USA.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|February 16, 2006
PubMed
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Stem cell terminology is confusing due to historical context and differing cell properties. Clarifying nomenclature by distinguishing between emergent and self-renewing stem cells is proposed for better understanding.

Area of Science:

  • Cell biology
  • Developmental biology
  • Histology

Background:

  • Current stem cell terminology is ambiguous, leading to confusion.
  • Historical biological concepts and contemporary debates over cell types contribute to this ambiguity.
  • The distinction between emergent and steady-state cell populations is central to the confusion.

Purpose of the Study:

  • To address the muddled nomenclature in stem cell research.
  • To propose a framework for clarifying stem cell definitions.
  • To differentiate between various stem cell properties and origins.

Main Methods:

  • Analysis of historical and contemporary stem cell definitions.
  • Examination of tissue dynamics and cell population classifications.

Related Experiment Videos

  • Codification of differences between emergent and steady-state cell populations.

    • Main Results:

    • Identified ambiguity stemming from historical biological concepts and common usage.
    • Highlighted confusion regarding whether stem cells belong to emergent or steady-state populations.
    • Proposed a distinction between embryonic stem (ES) and embryonic germ (EG) cells in culture versus self-renewing (SR) cells in steady-state populations.

    Conclusions:

    • Stem cell nomenclature requires clarification to resolve ambiguity.
    • Distinguishing between cell types based on population dynamics (emergent vs. steady-state) is crucial.
    • A codified system differentiating cell types will enhance scientific understanding and communication.