Related Experiment Video
Updated: Aug 18, 2026

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
Published on: May 27, 2011
Activation of Epstein-Barr virus promoters by a growth-factor and a glucocorticoid
C Schuster1, S Chasserot-Golaz, G Beck
1Institut de Biologie Moléculaire et Cellulaire du CNRS, Strasbourg, France.
Abstract:
Transforming growth factor-beta (TGF-beta) and a glucocorticosteroid, Dexamethasone (DXM), both cause transcriptional induction of Epstein-Barr virus (EBV) early antigens (EA) in Daudi lymphoma cells. The viral induction occurs through the viral promoter DR overlapping an origin of replication which is active during the lytic cycle. Each hormone requires specific regions on the DR promoter. Since these regions also mediate the action of two viral transcription factors, EB1 and R, it may be emphasized that EB1 and/or R are involved in the EA induction process by TGF-beta and by DXM.
Related Concept Videos
Mitogens and the Cell Cycle
Abnormal Proliferation
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
TGF - β Signaling Pathway
B Cell Activation and Differentiation
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...

