Related Experiment Video
Updated: Jul 31, 2026

Internalization and Observation of Fluorescent Biomolecules in Living Microorganisms via Electroporation
Published on: February 8, 2015
Infrared two-photon-excited visible lasing from a DNA-surfactant-chromophore complex
Guang S He1, Qingdong Zheng, Paras N Prasad
1Institute for Lasers, Photonics and Biophotonics, State University of New York at Buffalo, New York 14260-3000, USA. gshe@acsu.buffalo.edu
Abstract:
Infrared two-photon-pumped and cavity-enhanced frequency upconversion lasing has been achieved in a novel DNA-surfactant-chromophore complex (DSCC) gel system, which is a new step toward producing a biological laser. Once the focused intensity of the 150 fs and approximately 775 nm pump laser beam is higher than a certain threshold level, highly directional stimulated emission at approximately 582 nm wavelength can be observed from a 1 cm long DSCC complex gel cell. With cavity feedback provided by the two optical windows, the pump threshold can be further reduced, the highly directional output lasing can be greatly enhanced, and the output spectral linewidth can be reduced to less than 1/5 of the spontaneous fluorescence spectral bandwidth.
Related Concept Videos
Labeling DNA Probes
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
Total Internal Reflection Fluorescence Microscopy

