Related Experiment Video
Updated: Jul 18, 2026
13:41
Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
Published on: March 8, 2012
Human papillomavirus type 16 DNA in anal cancers from six different countries
J H Scholefield1, I B Kerr, N A Shepherd
1Imperial Cancer Research Fund, Colorectal Unit, St Mark's Hospital, London.
Gut
|June 1, 1991
Summary
Human papillomavirus (HPV) type 16 DNA is linked to anal squamous cell carcinoma globally. This study found HPV type 16 in 29% of samples, with lower prevalence in India and South Africa.
Area of Science:
- Oncology
- Virology
- Epidemiology
Background:
- A known association exists between anal squamous cell carcinoma (SCC) and human papillomavirus (HPV) type 16 DNA in the UK.
- If HPV type 16 is a key etiological factor, its presence would be expected in anal cancer tissues worldwide.
Purpose of the Study:
- To investigate the global prevalence of HPV type 16 DNA in anal squamous cell carcinoma tissues.
- To compare the occurrence of HPV-associated anal SCC across different international centers.
Main Methods:
- Examined 173 anal squamous cell carcinoma tissue samples from five global centers.
- Utilized DNA hybridisation techniques to detect HPV type 16 DNA sequences.
Main Results:
- HPV type 16 DNA was detected in 50 out of 173 (29%) of the analyzed samples.
- Prevalence of HPV-associated anal SCC was significantly lower in samples from India and South Africa compared to Switzerland, Poland, and Brazil.
Conclusions:
- HPV-associated anal squamous cell carcinoma occurs in various countries globally.
- Further research is needed to explore the association of anal SCC with other HPV types and their geographical distribution.
