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Intrasinusoidal bone marrow infiltration and splenic marginal zone lymphoma: a quantitative study
Achille Pich1, Flavio Fraire, Alessandro Fornari
1Department of Biomedical Sciences and Human Oncology, Section of Pathology, University of Turin, Turin, Italy. achille.pich@.unito.it
European Journal of Haematology
|February 17, 2006
Summary
Intrasinusoidal infiltration (ISI) in bone marrow biopsies is not a reliable diagnostic marker for splenic marginal zone cell lymphoma (SMZL). Study findings show no significant difference in ISI quantity across various lymphoma subtypes.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Intrasinusoidal infiltration (ISI) on bone marrow (BM) biopsies is considered a hallmark of splenic marginal zone cell lymphoma (SMZL).
- The diagnostic utility of ISI quantity in BM biopsies for SMZL requires further investigation.
Purpose of the Study:
- To evaluate whether the quantity of intrasinusoidal infiltration (ISI) in bone marrow (BM) biopsies serves as a reliable diagnostic criterion for splenic marginal zone cell lymphoma (SMZL).
Main Methods:
- Analysis of BM biopsies from 54 patients with various lymphoma types, including SMZL.
- Quantification of total infiltrate (TI) and intrasinusoidal infiltrate (ISI) using CD45, CD20, and CD3 stained sections.
- Calculation of mean percentages of TI and ISI in 10 areas per case.
Main Results:
- No significant difference in ISI quantity was observed between primary splenic lymphoma (PSL) and non-PSL groups.
- ISI quantity did not differ significantly between SMZL and other types of PSL.
- No significant difference in ISI quantity was found among various lymphoma subtypes in either PSL or non-PSL groups.
Conclusions:
- The quantity of intrasinusoidal infiltration (ISI) in bone marrow (BM) biopsies is not a dependable diagnostic parameter for identifying splenic marginal zone cell lymphoma (SMZL).
- Further research may be needed to identify definitive diagnostic markers for SMZL.