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Related Experiment Videos

Bone resorption markers in vitamin D insufficiency.

Allan G Need1

  • 1Department of Clinical Biochemistry, Institute of Medical and Veterinary Science, Frome Road, Adelaide, South Australia 5000, Australia. allan.need@imvs.sa.gov.au

Clinica Chimica Acta; International Journal of Clinical Chemistry
|February 17, 2006
PubMed
Summary

Vitamin D insufficiency, even without severe deficiency, negatively impacts bone health and increases fracture risk. Maintaining adequate vitamin D (serum 25(OH)D) levels above 50 nmol/L is crucial, especially for the elderly.

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Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Nutritional Science

Background:

  • Vitamin D deficiency (serum 25(OH)D < 12.5 nmol/L) causes rickets and osteomalacia.
  • Lesser degrees of vitamin D insufficiency have detrimental effects on bone and other organs.
  • Impaired bone mineralization and increased parathyroid hormone (PTH) are linked to falling 25(OH)D levels below 50 nmol/L.

Purpose of the Study:

  • To review the evidence linking vitamin D insufficiency to adverse bone health outcomes.
  • To highlight the association between low vitamin D levels and increased bone resorption and fracture risk.
  • To establish consensus on optimal vitamin D levels for fracture prevention in the elderly.

Main Methods:

  • Review of existing studies on vitamin D levels, bone metabolism markers, and fracture risk.

Related Experiment Videos

  • Analysis of data from hip fracture patients, hospital inpatients, and outpatients.
  • Examination of relationships between serum 25(OH)D, PTH, alkaline phosphatase (ALP), and bone resorption markers.

    • Main Results:

    • Vitamin D insufficiency is prevalent in hospital inpatients (57%) and outpatients (35%).
    • Low serum 25(OH)D levels correlate with elevated PTH and alkaline phosphatase (ALP).
    • Increased bone resorption markers (urine hydroxyproline, pyridinium cross-links) are inversely related to serum 25(OH)D.

    Conclusions:

    • Vitamin D insufficiency contributes to increased bone resorption, potentially leading to osteoporosis and higher fracture risk.
    • Maintaining serum 25(OH)D levels at or above 50 nmol/L is recommended for the elderly to minimize fractures.
    • Optimal bone resorption marker levels in the elderly may be similar to premenopausal women.