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Dipeptide nitrile inhibitors of cathepsin K

Eva Altmann1, Reiner Aichholz, Claudia Betschart

  • 1Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland. eva.altmann@novartis.com

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Enzyme Inhibition

Inhibitors are molecules that reduce enzyme activity by binding to the enzyme. In a normally functioning cell, enzymes are regulated by a variety of inhibitors. Drugs and other toxins can also inhibit enzymes. Some inhibitors bind to the enzyme’s active site, while others inhibit enzymatic activity by binding to other sites on the protein structure.