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Experimental implementation of identification-based optimizing control of a simulated moving bed process.

In-Hyoup Song1, Mohammad Amanullah, Gültekin Erdem

  • 1ETH-Zurich, Institute of Process Engineering, 8092 Zürich, Switzerland.

Journal of Chromatography. A
|February 17, 2006
PubMed
Summary

This study reports an optimizing controller for simulated moving bed (SMB) units, enhancing nucleoside separation. The controller achieves optimal performance and effectively manages operational disturbances.

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Area of Science:

  • Chemical Engineering
  • Separation Science
  • Process Control

Background:

  • Simulated Moving Bed (SMB) chromatography is a key technology for continuous separation processes.
  • Optimizing controller design is crucial for enhancing SMB unit efficiency and product purity.
  • Nucleoside separation presents challenges due to similar chemical properties.

Purpose of the Study:

  • To experimentally implement and validate an optimizing controller for nucleoside separation in a laboratory-scale SMB unit.
  • To assess the controller's performance based on productivity, solvent consumption, and stream purities.
  • To evaluate the controller's ability to maintain optimal operation and reject disturbances.

Main Methods:

  • Development of an optimizing controller based on an identified model of the SMB unit.

Related Experiment Videos

  • Experimental setup utilizing a laboratory-scale SMB unit for nucleoside separation.
  • Online monitoring of extract and raffinate concentrations using ultraviolet (UV) detectors for feedback control.
  • Manipulation of three external and one internal flow rates as control variables.

    • Main Results:

    • The designed controller successfully operated the SMB unit under optimal conditions.
    • Purity requirements for both extract and raffinate streams were consistently met.
    • The controller demonstrated robust performance in rejecting process disturbances.
    • Achieved high productivity and efficient solvent consumption under controlled conditions.

    Conclusions:

    • The experimental implementation of the optimizing controller is successful for nucleoside separation in SMB units.
    • The developed controller ensures efficient and stable operation, meeting stringent purity standards.
    • This approach offers a reliable method for enhancing the performance and robustness of SMB separation processes.