Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Inactive renin levels in recurrent nephroblastoma.

M A Johnston1, R Carachi, G B Lindop

  • 1Department of Surgical Paediatrics, Royal Hospital for Sick Children, Glasgow, Scotland.

Journal of Pediatric Surgery
|May 1, 1991
PubMed
Summary

Plasma inactive renin levels may indicate recurrence in children with nephroblastoma. Elevated levels at diagnosis and recurrence suggest inactive renin could serve as a valuable tumor marker for this childhood kidney cancer.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Survey of Various Foods for the Presence of Listeria Species.

Journal of food protection·2019
Same author

Microbiological Quality of Fresh and Frozen Breakfast-Type Sausages Sold in Canada.

Journal of food protection·2019
Same author

A systematic review and meta-analysis revealing realistic outcomes following paediatric torsion of testes.

Journal of pediatric urology·2018
Same author

Genetic homogeneity of the invasive lionfish across the Northwestern Atlantic and the Gulf of Mexico based on Single Nucleotide Polymorphisms.

Scientific reports·2018
Same author

The Dan Young Neonatal Surgical Unit audit: an audit of admissions and mortality rates pre- and post-amalgamation.

Scottish medical journal·2015
Same author

Clinical embryology: is there still a place in medical schools today?

Scottish medical journal·2014

Area of Science:

  • Pediatric Oncology
  • Biochemical Markers
  • Renal Tumors

Background:

  • Nephroblastoma (Wilms tumor) is a common childhood kidney cancer.
  • Identifying reliable tumor markers is crucial for monitoring disease recurrence and treatment effectiveness.

Purpose of the Study:

  • To investigate the potential of plasma inactive renin as a tumor marker for nephroblastoma.
  • To assess inactive renin levels in children with primary and recurrent nephroblastoma.

Main Methods:

  • Prospective study involving four children diagnosed with nephroblastoma.
  • Measurement of plasma inactive renin levels at initial presentation, during recurrent disease, and post-treatment.

Main Results:

  • Elevated plasma inactive renin levels were observed in three of four children at initial nephroblastoma diagnosis.

Related Experiment Videos

  • All four children showed elevated inactive renin levels upon detection of recurrent disease.
  • Inactive renin levels normalized after surgical intervention and chemotherapy.

    • Conclusions:

    • Plasma inactive renin may serve as a useful tumor marker for detecting nephroblastoma recurrence in children.
    • Monitoring inactive renin levels could aid in the management of pediatric nephroblastoma.