Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Primary biliary cirrhosis in India.

Shiv Kumar Sarin1, Rajnish Monga, Bimaljeet Singh Sandhu

  • 1Department of Gastroenterology, G.B. Pant Hospital, New Delhi-110002, India. sksarin@nda.vanl.net.in

Hepatobiliary & Pancreatic Diseases International : HBPD INT
|February 17, 2006
PubMed
Summary

Primary biliary cirrhosis (PBC) is rare in India. Unlike in the West, Indian PBC patients present late with cirrhosis and decompensation, highlighting a need for earlier diagnosis of this chronic liver disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Laparoscopic versus open pancreaticoduodenectomy in patients with periampullary carcinoma: A randomised clinical trial.

Journal of minimal access surgery·2026
Same author

A multisociety consensus statement on a new common definition and diagnostic criteria for PSVD or NCPF.

Hepatology international·2026
Same author

A multisociety consensus statement on a new common definition and diagnostic criteria for PSVD or NCPF.

Hepatology (Baltimore, Md.)·2026
Same author

A multisociety consensus statement on a new common definition and diagnostic criteria for PSVD or NCPF.

Annals of hepatology·2026
Same author

A multisociety consensus statement on a new common definition and diagnostic criteria for PSVD or NCPF.

Journal of hepatology·2026
Same author

Outcomes of Nucleos(t)ide Analogue Discontinuation in Noncirrhotic Patients With Chronic Hepatitis B: A Retrospective Study.

Cureus·2026

Area of Science:

  • Hepatology
  • Autoimmune Diseases
  • Gastroenterology

Background:

  • Primary biliary cirrhosis (PBC) is an uncommon cause of chronic liver disease in India.
  • A 10-year analysis was conducted to understand the clinical, biochemical, serological, and histological characteristics of Indian PBC patients.

Purpose of the Study:

  • To characterize the clinical presentation and disease features of Primary Biliary Cirrhosis (PBC) in an Indian population.
  • To compare the presentation of PBC in India with that observed in Western countries.

Main Methods:

  • Diagnosis of PBC was based on elevated serum alkaline phosphatase (ALP), anti-mitochondrial antibody (AMA) positivity, and/or liver histology.
  • Clinical data, biochemical markers, serological tests, and liver biopsy results were analyzed for 15 female patients.

Related Experiment Videos

Main Results:

  • The study included 15 female patients with a mean age of 46.5 years. Common symptoms included pruritus (80%), jaundice (67%), and fatigue (60%).
  • Hepatomegaly was observed in 87% of patients, and 40% presented with ascites. Liver biopsies revealed PBC stages II-III in 8 patients and cirrhosis in 5.
  • Anti-mitochondrial antibody (AMA) was positive in all patients, with 53% also positive for anti-nuclear or anti-smooth muscle antibodies. Associated autoimmune disorders were present in 33% of patients.

Conclusions:

  • Primary Biliary Cirrhosis (PBC) is a rare but significant cause of chronic liver disease in India.
  • PBC in India tends to present later than in Western countries, often with advanced disease features like cirrhosis and decompensation.