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Related Experiment Videos

The DIMA web resource--exploring the protein domain network.

Philipp Pagel1, Matthias Oesterheld, Volker Stümpflen

  • 1Department of Genome Oriented Bioinformatics, Technical University of Munich, Wissenschaftszentrum Weihenstephan, 85350 Freising, Germany. p.pagel@gsf.de

Bioinformatics (Oxford, England)
|February 17, 2006
PubMed
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Explore protein domain interactions with DIMA, a novel web resource. DIMA integrates multiple data sources and prediction methods to visualize and analyze domain networks, offering new insights beyond protein-level analysis.

Area of Science:

  • Proteomics
  • Bioinformatics
  • Structural Biology

Background:

  • Conserved protein domains act as functional modules, forming interaction networks.
  • Domain-based networks offer novel biological information compared to protein-level networks.
  • The Domain Interaction MAp (DIMA) is a new web resource for exploring these networks.

Purpose of the Study:

  • To present a comprehensive web resource, DIMA, for interactively exploring protein domain interaction networks.
  • To integrate diverse data sources and prediction techniques for network analysis.
  • To provide users with tools to compute, visualize, navigate, and download domain networks.

Main Methods:

  • Integration of multiple data sources for domain interactions.
  • Implementation of domain phylogenetic profiling for network inference.

Related Experiment Videos

  • Inclusion of experimentally determined domain contacts from 3D structures.
  • Development of a user-friendly interface for network exploration.

    • Main Results:

    • DIMA provides a comprehensive platform for exploring domain interaction networks.
    • The resource integrates data from phylogenetic profiling and structural studies.
    • Users can interactively compute, visualize, navigate, and download domain networks.

    Conclusions:

    • Domain interaction networks offer valuable biological insights.
    • DIMA serves as a powerful tool for researchers studying protein function and evolution.
    • The interactive nature of DIMA facilitates novel discoveries in protein interaction studies.