Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bacterial Phylum Chlamydiae01:29

Bacterial Phylum Chlamydiae

The phylum Chlamydiae or Chlamydiota is composed of a single order, Chlamydiales. This phylum consists entirely of obligate intracellular parasites that infect eukaryotic hosts. While human pathogens within this group have been studied extensively, the phylum encompasses many species capable of interacting with various eukaryotic organisms. Members of Chlamydiae are typically small cocci, approximately 0.5 μm in diameter, and exhibit a distinctive developmental cycle. As is characteristic of...
Diversity of Protists II01:27

Diversity of Protists II

Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
Inhalation Anthrax01:25

Inhalation Anthrax

Anthrax is a zoonotic disease caused by Bacillus anthracis, a Gram-positive, spore-forming bacterium. It primarily affects herbivorous animals but can be transmitted to humans through skin contact, ingestion, or inhalation of spores.Cutaneous anthrax, the most common form, typically results from direct contact with bacterial spores through skin abrasions and is generally less severe. Gastrointestinal anthrax results from eating undercooked or contaminated meat. It affects the mouth, throat, or...
Plague01:24

Plague

Plague is a highly virulent zoonotic disease caused by Yersinia pestis, a Gram-negative, facultatively anaerobic coccobacillus. This pathogen primarily circulates among rodent populations and is transmitted to humans through the bite of infected fleas. Additional transmission routes include direct contact with infected animal tissue or inhalation of respiratory droplets from individuals with pneumonic plague. These multiple transmission pathways highlight the bacterium’s potential for rapid...
Malaria01:29

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...
Amebiasis01:28

Amebiasis

Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

EPR spectroscopy reveals antioxidant manganese defenses in the Lyme disease pathogen <i>Borrelia burgdorferi</i>.

mBio·2025
Same author

What's in a Name? How Useful is Current Rickettsial Taxonomy and Is Revision of Nomenclature Needed?

The American journal of tropical medicine and hygiene·2025
Same author

Rickettsioses as Underrecognized Cause of Hospitalization for Febrile Illness, Uganda.

Emerging infectious diseases·2025
Same author

<i>Borrelia burgdorferi</i> radiosensitivity and Mn antioxidant content: antigenic preservation and pathobiology.

mBio·2024
Same author

Genomics Should Inform Appropriate Analysis of Taxonomy and Pathogenesis of Rickettsia.

The Journal of infectious diseases·2024
Same author

Culture and other direct detection methods to diagnose human granulocytic anaplasmosis.

American journal of clinical pathology·2024

Related Experiment Video

Updated: Jul 1, 2026

Loop-mediated Isothermal Amplification (LAMP) Assays for the Species-specific Detection of Eimeria that Infect Chickens
06:57

Loop-mediated Isothermal Amplification (LAMP) Assays for the Species-specific Detection of Eimeria that Infect Chickens

Published on: February 20, 2015

Anaplasma and Ehrlichia infection.

J Stephen Dumler1

  • 1Division of Medical Microbiology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. sdumler@jhmi.edu

Annals of the New York Academy of Sciences
|February 17, 2006
PubMed
Summary

Anaplasmataceae infections, transmitted by arthropods, are a growing global health concern. Understanding bacterial and host factors is key to controlling these potentially fatal ehrlichiosis and anaplasmosis diseases.

Area of Science:

  • Veterinary Medicine
  • Infectious Diseases
  • Microbiology

Background:

  • Anaplasmataceae infections are increasingly recognized as significant arthropod-transmitted diseases in humans and animals.
  • The incidence of infections by Ehrlichia chaffeensis and Anaplasma phagocytophilum has risen since diagnostic methods were established.
  • Global distribution and ongoing identification of new agents highlight the expanding threat of ehrlichiosis and anaplasmosis.

Purpose of the Study:

  • To emphasize the growing importance and severity of Anaplasmataceae infections.
  • To highlight the need for fundamental research into disease pathophysiology and pathogenesis.
  • To underscore the critical role of host-pathogen interactions in disease manifestation and bacterial survival.

Main Methods:

More Related Videos

Nucleofection and In Vivo Propagation of Chicken Eimeria Parasites
08:26

Nucleofection and In Vivo Propagation of Chicken Eimeria Parasites

Published on: February 14, 2020

Isolation And Dendritic Cell-Uptake of Small Extracellular Vesicles from Echinococcus granulosus
09:04

Isolation And Dendritic Cell-Uptake of Small Extracellular Vesicles from Echinococcus granulosus

Published on: March 28, 2025

Related Experiment Videos

Last Updated: Jul 1, 2026

Loop-mediated Isothermal Amplification (LAMP) Assays for the Species-specific Detection of Eimeria that Infect Chickens
06:57

Loop-mediated Isothermal Amplification (LAMP) Assays for the Species-specific Detection of Eimeria that Infect Chickens

Published on: February 20, 2015

Nucleofection and In Vivo Propagation of Chicken Eimeria Parasites
08:26

Nucleofection and In Vivo Propagation of Chicken Eimeria Parasites

Published on: February 14, 2020

Isolation And Dendritic Cell-Uptake of Small Extracellular Vesicles from Echinococcus granulosus
09:04

Isolation And Dendritic Cell-Uptake of Small Extracellular Vesicles from Echinococcus granulosus

Published on: March 28, 2025

  • Review of diagnostic and epidemiological data on Anaplasmataceae infections.
  • Analysis of clinical manifestations and complications associated with these diseases.
  • Exploration of host immune responses, including neutrophil function and innate/adaptive immunity.

    • Main Results:

    • Anaplasmataceae infections are globally distributed and present with increasing incidence.
    • Severe complications requiring hospitalization occur in about half of patients, with mortality rates of 0.5-3.0%.
    • Host factors, including neutrophil function and immune system alterations, significantly contribute to disease severity and bacterial survival.

    Conclusions:

    • Further fundamental research is crucial for understanding Anaplasmataceae biology, pathophysiology, and pathogenesis.
    • Investigating the interplay between bacterial virulence and host immune responses is essential.
    • A stronger scientific basis will enable rational strategies for infection control, prevention, and treatment of ehrlichiosis and anaplasmosis.