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  3. Calcium Plus Vitamin D Supplementation And The Risk Of Colorectal Cancer.
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  3. Calcium Plus Vitamin D Supplementation And The Risk Of Colorectal Cancer.

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Calcium plus vitamin D supplementation and the risk of colorectal cancer.

Jean Wactawski-Wende1, Jane Morley Kotchen, Garnet L Anderson

  • 1Department of Social and Preventive Medicine, University at Buffalo, 270 Farber Hall, Buffalo, NY 14214, USA. jww@buffalo.edu

The New England Journal of Medicine
|February 17, 2006

View abstract on PubMed

Summary
This summary is machine-generated.

Calcium and vitamin D supplements did not reduce colorectal cancer risk in postmenopausal women over seven years. Further research is needed to understand the long-term effects of supplementation on cancer prevention.

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Area of Science:

  • Oncology
  • Nutritional Science
  • Epidemiology

Background:

  • Observational studies suggest calcium and vitamin D intake may lower colorectal cancer risk.
  • Randomized trial evidence for primary prevention of colorectal cancer with calcium and vitamin D supplementation is limited.

Purpose of the Study:

  • To evaluate the efficacy of calcium with vitamin D supplementation in the primary prevention of colorectal cancer in postmenopausal women.

Main Methods:

  • A randomized, double-blind, placebo-controlled trial involving 36,282 postmenopausal women.
  • Participants received either calcium (1000 mg/day) plus vitamin D (400 IU/day) or a placebo for an average of 7.0 years.
  • Colorectal cancer incidence was assessed as a secondary outcome.

Main Results:

  • No significant difference in colorectal cancer incidence was observed between the calcium-vitamin D group and the placebo group (HR, 1.08; P=0.51).
  • Tumor characteristics, screening frequency, and reported symptoms were similar between groups.
  • No significant treatment interactions were found with baseline characteristics.

Conclusions:

  • Seven-year daily supplementation with calcium and vitamin D did not impact colorectal cancer incidence in postmenopausal women.
  • The null finding may be attributed to the long latency of colorectal cancer and the trial's duration.
  • Longer-term follow-up is ongoing to assess the intervention's sustained effects.