Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functional genomics in hypertension.

Martin W McBride1, Delyth Graham, Christian Delles

  • 1BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.

Current Opinion in Nephrology and Hypertension
|February 17, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Increased expression of aromatase after focal cerebral ischemia: Relevance to neuroprotection and functional recovery.

Neuroprotection (Chichester, England)·2026
Same author

Hypertension in 2025: are we ready for bold precision public health approaches worldwide?

Nature reviews. Cardiology·2025
Same author

Is It Time to Abandon the Kidney-Centered View on the Origin of Primary Hypertension?

Hypertension (Dallas, Tex. : 1979)·2025
Same author

Insights into Uromodulin and Blood Pressure.

Current hypertension reports·2024
Same author

<i>UMOD</i> Genotype-Blinded Trial of Ambulatory Blood Pressure Response to Torasemide.

Hypertension (Dallas, Tex. : 1979)·2024
Same author

Assessing Machine Learning for Diagnostic Classification of Hypertension Types Identified by Ambulatory Blood Pressure Monitoring.

CJC open·2024

Unraveling the genetic basis of essential hypertension requires advanced genotyping and functional analysis. New tools and animal models are improving our understanding of cardiovascular genomics for targeted treatments.

Area of Science:

  • Cardiovascular Genomics
  • Hypertension Research
  • Genetic Epidemiology

Background:

  • Essential hypertension is a complex polygenic disease with significant global health implications.
  • Advances in genotyping technology and functional analysis are crucial for understanding its genetic underpinnings.

Purpose of the Study:

  • To review recent advances in identifying and analyzing genes associated with hypertension.
  • To explore the role of animal models and emerging technologies in hypertension research.

Main Methods:

  • Genome-wide scans to identify chromosomal loci linked to hypertension.
  • High-throughput genotyping for single-nucleotide polymorphism analysis.
  • Utilizing animal models (congenic strains, transgenic models) and techniques like RNA interference.

Related Experiment Videos

  • Analyzing conserved synteny between species for translational relevance.
  • Investigating microRNA regulation and proteomics.

    • Main Results:

    • Identification of chromosomal loci associated with hypertension in humans.
    • Development of tools for analyzing gene-function relationships in hypertension.
    • Demonstration of the utility of animal models and conserved synteny for human hypertension research.

    Conclusions:

    • The genetic basis of hypertension is complex, with functional consequence analysis remaining a challenge.
    • Emerging tools enhance the study of gene-function relationships, advancing cardiovascular genomics.
    • Improved understanding will facilitate targeted prevention and treatment strategies for hypertension and cardiovascular diseases.