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Updated: Aug 11, 2026

Laser-Induced Action Potential-Like Measurements of Cardiomyocytes on Microelectrode Arrays for Increased Predictivity of Safety Pharmacology
Published on: September 13, 2022
[Electrical instability of the myocardium in patients with acquired heart defects.]
R A Abdueva1, V V Samoĭlenko, V I Makolkin
1I.M. Sechenov Moscow Medical Academy; ul. Bolshaya Pirogovskaya, 2/6, 119881 Moscow, Russia.
Abstract:
Aim of the study was to investigate electrophysiological state of the myocardium and conduct comparative analysis of informative power of methods of dipole electrocardiography and signal averaged ECG with detection of late ventricular potentials for prognostication of ventricular heart rhythm disturbances in patients with acquired heart defects. Examination of 43 patients with acquired heart defects showed that patients with high grade ventricular extrasystoles significantly more often had late ventricular potentials, prolonged interval corresponding to maximal values of activation area, area of fresh activation, and diminished vector of repolarization acceleration and its components.
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