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Updated: Aug 11, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
Published on: September 14, 2010
Looking for the target cell of Kaposi's sarcoma-associated herpesvirus
Nicolas Dupin1, Philippe A Grange
1Service de Dermatologie, Hôpital Cochin, Laboratoire de Recherche en Dermatologie, Unité UPRES1833, Faculté de Médecine Paris V, Université René Descartes, Paris, France. nicolas.dupin@cch.ap-hop-paris.fr
Abstract:
The level of Kaposi's sarcoma-associated herpesvirus (KSHV) cellular viremia in patients with Kaposi's sarcoma could be related to both the tumor burden and its progression. The origin of the spindle cell, the hallmark cell of Kaposi's sarcoma, is still debated. Two hypotheses may be formulated, favoring a lymphatic endothelial cell or an endothelial-cell precursor evolving into a lymphatic phenotype, both preferentially targeted by KSHV.
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