Related Experiment Video

Updated: Aug 11, 2026

Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy
09:57

Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy

Published on: September 20, 2024

Intravenous lidocaine for status epilepticus during childhood

Shin-ichiro Hamano1, Nobuyoshi Sugiyama, Shintaro Yamashita

  • 1Division of Neurology, Saitama Children's Medical Center, Japan. a1091170@pref.saitama.lg.jp

Developmental Medicine and Child Neurology
|February 18, 2006
PubMed

Insights

Lidocaine shows limited efficacy for convulsive status epilepticus in children, controlling seizures in only 35.8% of cases. While it acts quickly with few side effects, its low response rate suggests it is not a primary treatment.

Area of Science:

  • Pediatric Neurology
  • Clinical Pharmacology

Background:

  • Convulsive status epilepticus (CSE) is a neurological emergency in children.
  • Current treatments for CSE have limitations, necessitating exploration of alternative agents.

Purpose of the Study:

  • To evaluate the clinical efficacy of lidocaine as an anticonvulsive agent for pediatric convulsive status epilepticus.
  • To assess the response rate and safety profile of lidocaine in this patient population.

Main Methods:

  • A retrospective analysis of 53 convulsive episodes in 37 children treated with lidocaine.
  • Data collected included patient demographics, seizure control, time to seizure cessation, and adverse events.
  • Efficacy was assessed based on seizure cessation following lidocaine administration.

Main Results:

  • Lidocaine controlled status epilepticus in 19 out of 53 episodes (35.8%).
  • In responsive patients, seizures ceased within 5 minutes of administration.
  • No statistical difference in effectiveness was observed based on etiology or seizure type.
  • One patient experienced mild oxygen desaturation, which resolved with oxygen therapy.
  • Favorable properties included prompt response, minimal alteration of consciousness, and limited adverse effects like respiratory depression.

Conclusions:

  • Lidocaine demonstrates a low response rate (35.8%) for pediatric convulsive status epilepticus.
  • Despite its favorable safety profile and rapid action, its limited efficacy suggests it may not be a first-line treatment.
  • Further research may explore optimal dosing or combination therapies to enhance lidocaine's effectiveness.

More Related Videos

Long-term Continuous EEG Monitoring in Small Rodent Models of Human Disease Using the Epoch Wireless Transmitter System08:43

Long-term Continuous EEG Monitoring in Small Rodent Models of Human Disease Using the Epoch Wireless Transmitter System

Published on: July 21, 2015

Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus08:28

Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus

Published on: April 5, 2011

Related Concept Videos

Cardiopulmonary Resuscitation IV: Pharmacological Management01:25

Cardiopulmonary Resuscitation IV: Pharmacological Management

Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia01:16

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
Epilepsy ll: Types01:22

Epilepsy ll: Types

Recurrent seizures, stemming from abnormal electrical activity in the brain, are the defining characteristic of epilepsy, a chronic neurological condition. Because seizure features vary greatly, epilepsy is classified using two systems: by seizure type and by epilepsy syndromes. These classifications enable clinicians to describe seizure patterns and select suitable treatment strategies.I. Classification by Seizure Type1. Focal EpilepsyFocal epilepsy begins in one hemisphere of the brain.