Novel indole inhibitors of IMPDH from fragments: synthesis and initial structure-activity relationships
Rebekah E Beevers1, George M Buckley, Natasha Davies
1UCB Celltech, Granta Park, Great Abington, Cambridge, CB1 6GS, UK.
Abstract:
The elaboration of previously reported indole fragments as inhibitors of inosine monophosphate dehydrogenase (IMPDH) is described. The synthesis, in vitro inhibitory values for IMPDH II, PBMC proliferation and physicochemical properties are discussed.
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