Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Phytosterols mixed with medium-chain triglycerides and high-oleic canola oil decrease plasma lipids in overweight

Iwona Rudkowska¹, Catherine E Roynette, Dilip K Nakhasi

¹School of Dietetics and Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, Montreal, Québec, Canada H9X 3V9.

Metabolism: Clinical and Experimental

|February 18, 2006

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Association of vitamin D Status with immune-associated serum protein pathways in overweight French-Canadian adults with hyperinsulinemia in the Quebec City metropolitan area, Canada.

The British journal of nutrition·2026

Same author

Impact of a whole food, plant-based diet on LDL-cholesterol and cardiovascular risk factors in adults with heterozygous familial hypercholesterolemia: a randomized, two-period, two-treatment, crossover, fully controlled feeding trial.

Nature communications·2026

Same author

Dairy Product Intake Alters the Correlations between Circulating Bile Acids and Short-Chain Fatty Acids with the Bacterial Taxa <italic>Roseburia</italic>, <italic>Faecalibacterium</italic>, <italic>Flavonifractor</italic>, and Verrucomicrobia.

Lifestyle genomics·2025

Same author

Secretory phospholipase A<sub>2</sub>-IIA targets bacterial extracellular vesicles to modulate immune signaling.

Communications biology·2025

Same author

Circulating Very Long-Chain Saturated Fatty Acids in Early Pregnancy: Association With Blood Pressure and Weight Gain.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC·2025

Same author

Impact of dairy intake on circulating fatty acids and associations with blood pressure: A randomized crossover trial.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2025

Phytosterols (PSs) in a functional oil blend significantly lowered LDL cholesterol in overweight, hyperlipidemic men. This dietary intervention suggests a potential reduction in cardiovascular event risk.

Area of Science:

Nutritional Science
Cardiovascular Health
Lipid Metabolism

Background:

Phytosterols (PSs) are increasingly incorporated into various food mediums.
Functional properties of matrices like medium-chain triglycerides (MCTs) require examination for synergistic benefits.
Overweight and hyperlipidemic individuals represent a key demographic for cardiovascular risk reduction strategies.

Purpose of the Study:

To evaluate the combined biological actions of a functional oil enriched with phytosterols (PSs) within a matrix of medium-chain triglycerides (MCTs) and high-oleic canola (HOC) oil.
To compare the effects of this functional oil against a control (olive oil) in overweight, hyperlipidemic men.
To assess the impact on lipid profiles and body weight through a controlled dietary intervention.

Main Methods:

Related Experiment Videos

A randomized, crossover trial involving 23 overweight, hyperlipidemic men.
Participants consumed both functional oil and olive oil for 6-week periods each.
Fasted plasma samples were collected, and body weight was monitored throughout the study.

Main Results:

Both oil treatments led to significant decreases in body weight.
The functional oil group showed significantly greater reductions in total cholesterol and low-density lipoprotein cholesterol (LDL-C) compared to the olive oil group.
High-density lipoprotein cholesterol levels remained unchanged, while triacylglycerol levels decreased similarly in both groups.

Conclusions:

Phytosterols (PSs) incorporated into an MCT- and HOC-rich matrix effectively lower plasma LDL-C in overweight, hyperlipidemic men.
This formulation does not significantly alter high-density lipoprotein cholesterol concentrations.
The findings suggest a potential role for this functional oil in reducing the risk of cardiovascular events.