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Normal and abnormal aggression: human disorders and novel laboratory models.

József Haller1, Menno R Kruk

  • 1Institute of Experimental Medicine, P.O. Box 67, 1450 Budapest, Hungary. haller@koki.hu

Neuroscience and Biobehavioral Reviews
|February 18, 2006
PubMed
Summary

Human aggressiveness stems from brain dysfunction, hypoarousal, or hyperarousal. New rodent models help assess abnormal aggression in psychopathologies and develop treatments.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Behavioral Science

Background:

  • Human aggressiveness is linked to psychopathologies.
  • Three major factors contribute to human aggressiveness: brain dysfunction, hypoarousal, and hyperarousal.

Purpose of the Study:

  • To review aggression-related human psychopathologies.
  • To propose three major factors contributing to human aggressiveness.
  • To introduce novel rodent models for assessing abnormal aggression.

Main Methods:

  • Review of existing literature on aggression-related psychopathologies.
  • Development and description of three rodent aggression models: hypoarousal-induced targeting, escalated aggression, and context-independent attacks.
  • Utilizing rodent models to simulate aspects of human aggression.

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Main Results:

  • Human aggressiveness is primarily attributed to brain dysfunction, hypoarousal (low glucocorticoids), and hyperarousal (irritability).
  • Different psychopathologies exhibit distinct aggressive behaviors (e.g., instrumental vs. outbursts).
  • Three rodent models effectively capture abnormal aggression dimensions relevant to human conditions.

Conclusions:

  • The proposed rodent models are valuable for evaluating psychopathologies, studying transgenic animals, and developing treatments for abnormal aggression.
  • These models focus on the qualitative aspects of abnormal aggression rather than quantitative measures.
  • Further research using these models can advance our understanding and treatment of aggression-related disorders.