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Related Experiment Videos

Diffuse pulmonary ossification: an uncommon incidental autopsy finding.

Jason Tseung1, Johan Duflou

  • 1Department of Forensic Medicine, Central Sydney Laboratory Service, Glebe, New South Wales, Australia. jason.tseung@email.cs.nsw.gov.au

Pathology
|February 18, 2006
PubMed
Summary
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Diffuse pulmonary ossification (DPO) is uncommon, found in 1.63 per 1000 autopsies, predominantly in males with lung disease. Dendriform DPO was more frequent than nodular DPO in this study.

Area of Science:

  • Pulmonary Pathology
  • Autopsy Studies
  • Histopathology

Background:

  • Diffuse pulmonary ossification (DPO) is a rare condition.
  • Diagnosis during life is infrequent.
  • Autopsy provides a means for identification.

Purpose of the Study:

  • Determine the incidence of DPO and its subtypes at autopsy.
  • Correlate DPO with clinical and histological findings.

Main Methods:

  • Retrospective review of autopsy reports over 64 months.
  • Analysis of ossification patterns, demographics, and clinical data.
  • Examination of paraffin sections and autopsy reports.

Main Results:

  • Seventeen cases of DPO identified in 10,426 autopsies (1.63/1000).

Related Experiment Videos

  • Predominance in males (88%) and individuals with underlying pulmonary disease (88%).
  • Dendriform DPO (11 cases) was more common than nodular DPO (6 cases), unlike previous reports. Dendriform type associated with marrow elements.

    • Conclusions:

    • DPO is an uncommon autopsy finding, rarely diagnosed antemortem.
    • Easily identifiable during lung examination at autopsy.
    • Renewed interest in DPO diagnosis and significance using HRCT and thoracoscopic biopsy.