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Abnormal exhaled ethane concentrations in scleroderma.

K A Cope1, S F Solga, L K Hummers

  • 1Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 20705, USA. kcope@jhsph.edu

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
|February 18, 2006
PubMed
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Patients with scleroderma show higher breath ethane levels, indicating increased oxidative stress. This biomarker may help detect disease-related cellular damage in systemic sclerosis.

Area of Science:

  • Biochemistry
  • Immunology
  • Pulmonology

Background:

  • Scleroderma (systemic sclerosis) is a chronic autoimmune disease.
  • Oxidative stress is implicated in scleroderma's pathophysiology.

Purpose of the Study:

  • To investigate if scleroderma patients exhibit elevated breath ethane concentrations.
  • To assess breath ethane as a biomarker for oxidative stress in scleroderma.

Main Methods:

  • Measured exhaled ethane concentrations in scleroderma patients (n=36) and healthy controls (n=21).
  • Analyzed correlations between ethane levels, medication use (calcium channel blockers), and lung function (carbon monoxide diffusion capacity).

Main Results:

  • Scleroderma patients had significantly higher mean breath ethane concentrations (5.27 pmol ml(-1) CO(2)) compared to controls (2.72 pmol ml(-1) CO(2)).

Related Experiment Videos

  • Patients on calcium channel blockers showed lower ethane levels (p=0.05).
  • A significant inverse association was found between lung diffusion capacity for carbon monoxide and ethane concentration (p=0.026).

    • Conclusions:

    • Breath ethane concentration is a valid indicator of increased oxidative stress in scleroderma patients.
    • These findings support the role of oxidative stress in systemic sclerosis pathogenesis.