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Lessons for clinical trials from natalizumab in multiple sclerosis

Abhijit Chaudhuri1

  • 1Essex Centre for Neurological Sciences, Oldchurch Hospital, Romford RM7 0BE. chaudhuria@gmail.com

BMJ (Clinical Research Ed.)
|February 18, 2006
PubMed
Summary

No abstract available in PubMed .

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Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.