Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Risk of multiple sclerosis after head injury: record linkage study.

M J Goldacre1, J D Abisgold, D G R Yeates

  • 1Unit of Health-Care, Department of Public Health, University of Oxford, Old Road Campus, Oxford OX3 7LF, UK. michael.goldacre@dphpc.ox.ac.uk

Journal of Neurology, Neurosurgery, and Psychiatry
|February 18, 2006
PubMed
Summary

Head injuries do not appear to increase the risk of developing multiple sclerosis (MS). This study found no significant association between head trauma and the onset or precipitation of MS.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Risk of self-harm in patients with eating disorders: English population-based national record-linkage study, 1999-2021.

The International journal of eating disorders·2023
Same author

Central nervous system abscesses and empyemas in England: epidemiological trends over five decades.

The Journal of infection·2023
Same author

Women with intellectual disability are at a higher risk of adverse maternal and offspring outcomes.

BJOG : an international journal of obstetrics and gynaecology·2016
Same author

Diagnostic outcomes following childhood non-specific abdominal pain: a record-linkage study.

Archives of disease in childhood·2015
Same author

Fall in population-based mortality from coronary heart disease negated in people with diabetes mellitus: data from England.

Diabetic medicine : a journal of the British Diabetic Association·2015
Same author

Age-specific risk of breast cancer in women with neurofibromatosis type 1.

British journal of cancer·2015

Area of Science:

  • Neurology
  • Epidemiology
  • Trauma Research

Background:

  • Previous research on head injury and multiple sclerosis (MS) development yielded inconclusive results.
  • Understanding potential environmental triggers for MS is crucial for prevention and management strategies.

Purpose of the Study:

  • To investigate the association between head injury and the subsequent risk of developing multiple sclerosis (MS).
  • To determine if head trauma acts as a risk factor for MS onset.

Main Methods:

  • Utilized a database of linked hospital and death records for cohort analysis.
  • Compared MS occurrence in individuals with head injuries against a matched reference cohort.
  • Assessed injury severity using length of hospital stay as a proxy.

Related Experiment Videos

Main Results:

  • The rate ratio for MS following head injury was 1.1 (95% CI, 0.88-1.36), indicating no significant increase in risk.
  • No significant MS risk increase was observed at short or long time intervals post-head injury.
  • Analysis by hospital stay duration (proxy for injury severity) showed no significant association with MS risk.

Conclusions:

  • Record linkage methodology minimized bias from patient recall or attribution.
  • Head injuries were not found to be associated with the etiological initiation of MS.
  • Head injuries did not appear to precipitate the clinical onset of multiple sclerosis.