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Rosai-Dorfman disease presenting as bilateral eyelid swellings
Sanjay Jogai1, Labiba Temmim, Abdullah Al-Baghli
1Department of Histopathology, Hussain Makki Juma Centre for Specialised Surgeries, Kuwait. sanjayjogai@rediffmail.com
Objective:
To report a case of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) in an extranodal site with unusual presentation.
Case Presentation:
A 19-year-old girl presented with bilateral upper eyelid swellings of 2 years duration due to tumor. The masses were excised and sent for histopathological examination. Microscopic examination revealed similar features in both masses in the form of a collection of large histiocytic cells showing emperipolesis (lymphocytophagocytosis). The histiocytic cells stained positively with S-100 protein and CD68. The background comprised small lymphocytes and plasma cells. Based on the overall features a diagnosis of sinus histiocytosis with massive lymphadenopathy or Rosai-Dorfman disease was made.
Conclusion:
The present case highlights one of the forms in which extranodal Rosai-Dorfman disease can manifest itself. It is important to keep this differential diagnosis in mind whenever such histopathological features are encountered.
