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06:38
A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
[Progress in therapeutic strategy for renal cell carcinoma]
Shigehiko Koga1, Hiroshi Kanetake
1Division of Nephro-Urology, Nagasaki University Graduate School of Biomedical Sciences.
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|February 18, 2006
Summary
Surgery is standard for renal cell carcinoma (RCC). Radiofrequency ablation (RFA) is a minimally invasive option for small tumors, while targeted therapies offer new hope for metastatic RCC.
Area of Science:
- Urology
- Oncology
- Minimally Invasive Surgery
Background:
- Renal cell carcinoma (RCC) is primarily treated with surgery.
- Partial nephrectomy is common for small RCC tumors.
- Radiofrequency ablation (RFA) presents a minimally invasive, nephron-sparing alternative.
Purpose of the Study:
- To review current treatment modalities for renal cell carcinoma (RCC).
- To evaluate the efficacy and safety of radiofrequency ablation (RFA) for small RCC.
- To discuss emerging targeted molecular therapies for metastatic RCC.
Main Methods:
- Review of surgical interventions for RCC, including partial nephrectomy.
- Analysis of radiofrequency ablation (RFA) as a treatment for small renal tumors (≤3 cm).
- Discussion of systemic therapies for metastatic RCC, including cytokine therapy and novel targeted agents.
Main Results:
- Radiofrequency ablation (RFA) demonstrates success in small renal tumors (≤3 cm) with a low rate of severe complications.
- Cytokine-based therapy offers transient responses and moderate survival benefits in a subset of metastatic RCC patients.
- Targeted molecular therapies show promise for improving efficacy in patients resistant to immunotherapy.
Conclusions:
- Radiofrequency ablation (RFA) is a viable minimally invasive option for select small renal cell carcinoma (RCC) cases.
- Further research is needed to establish the long-term efficacy of RFA in RCC.
- Development of targeted molecular therapies and combined treatment modalities is crucial for improving outcomes in metastatic RCC.
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