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Epigenetic therapy of cancer: past, present and future

Christine B Yoo1, Peter A Jones

  • 1USC/Norris Comprehensive Cancer Center, Department of Urology, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, California 90089, USA.

Nature Reviews. Drug Discovery
|February 18, 2006
PubMed

Insights

Epigenetic aberrations in cancer are reversible, unlike genetic mutations. Targeting these epigenetic changes offers a promising new strategy for cancer treatment and prevention.

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Cancer development involves both genetic and epigenetic alterations.
  • Epigenetic changes, unlike genetic mutations, are potentially reversible.
  • Reversing epigenetic aberrations may restore normal cell function.

Purpose of the Study:

  • To highlight the potential of targeting epigenetic modifications in cancer therapy.
  • To discuss the role of epigenetic drugs in chemotherapy and cancer chemoprevention.

Main Methods:

  • Review of current research on epigenetic regulation in cancer.
  • Analysis of emerging drugs targeting epigenetic enzymes.
  • Evaluation of epigenetic therapy in preclinical and clinical settings.

Main Results:

  • Epigenetic modifications are crucial drivers of cancer initiation and progression.
  • Targeted epigenetic therapies demonstrate potential for cancer treatment.
  • Reversibility of epigenetic changes offers therapeutic advantages.

Conclusions:

  • Epigenetic targeting represents a significant advancement in cancer treatment and prevention.
  • Drugs modulating epigenetic enzymes are valuable tools in oncology.
  • Further research into epigenetic therapies is warranted for improved cancer outcomes.

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