Related Experiment Video
Updated: Aug 11, 2026

Quantifying Human Norovirus Virus-like Particles Binding to Commensal Bacteria Using Flow Cytometry
Published on: April 29, 2020
Porcine noroviruses related to human noroviruses
Qiu-Hong Wang1, Myung Guk Han, Sonia Cheetham
1Food Animal Health Research Program, The Ohio State University, Wooster, Ohio 44691, USA.
Abstract:
Detection of genogroup II (GII) norovirus (NoV) RNA from adult pigs in Japan and Europe and GII NoV antibodies in US swine raises public health concerns about zoonotic transmission of porcine NoVs to humans, although no NoVs have been detected in US swine. To detect porcine NoVs and to investigate their genetic diversity and relatedness to human NoVs, 275 fecal samples from normal US adult swine were screened by reverse transcription-polymerase chain reaction with calicivirus universal primers. Six samples were positive for NoV. Based on sequence analysis of 3 kb on the 3' end of 5 porcine NoVs, 3 genotypes in GII and a potential recombinant were identified. One genotype of porcine NoVs was genetically and antigenically related to human NoVs and replicated in gnotobiotic pigs. These results raise concerns of whether subclinically infected adult swine may be reservoirs of new human NoVs or if porcine/human GII recombinants could emerge.
Related Concept Videos
Viral Recombination
Poliomyelitis
Coronavirus
Human Virome
Bacteriophages of the Human Virome
Bacterial Gastroenteritis

