Related Experiment Video
Updated: Aug 11, 2026
06:35
Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
Published on: June 28, 2021
[Recurrent acute pancreatitis during pravastatin-therapy]
C Becker1, C Hvalic, G Delmore
1Klinische Pharmakologie und Toxikologie, Universitätsspital Basel. beckerc@uhbs.ch
Praxis
|February 21, 2006
Summary
Drug-induced acute pancreatitis is rare but linked to various medications. This case report details a patient experiencing recurrent acute pancreatitis while using pravastatin, a statin, highlighting complex treatment considerations.
Area of Science:
- Pharmacology
- Gastroenterology
- Internal Medicine
Background:
- Acute pancreatitis is an uncommon drug-induced condition.
- Hydroxymethylglutaryl-CoA-reductase inhibitors (statins) have been individually linked to acute pancreatitis.
- Limited data exists on rare adverse reactions to ezetimibe and pancreatitis associated with fibrates.
Observation:
- A 60-year-old male experienced two episodes of acute pancreatitis during pravastatin therapy.
- This case highlights a potential association between pravastatin and acute pancreatitis.
- Previous reports suggest pancreatitis may recur with different statin agents.
Findings:
- Pravastatin, a statin, was associated with recurrent acute pancreatitis in a male patient.
- The literature indicates potential cross-reactivity among different statins regarding pancreatitis risk.
- Fibrates are also linked to pancreatitis, and ezetimibe's adverse reaction profile is not well-established.
Implications:
- Clinicians should consider drug-induced pancreatitis in patients presenting with acute pancreatitis, especially those on statins.
- Careful patient monitoring and consideration of alternative lipid-lowering agents may be necessary.
- Further research is needed to elucidate the mechanisms and incidence of statin-associated pancreatitis and guide therapeutic recommendations.
Related Concept Videos
01:25Acute Pancreatitis I: Introduction
Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
01:27Acute Pancreatitis I: Introduction
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
01:21Chronic Pancreatitis II: Pathophysiology
Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
01:25Chronic Pancreatitis I: Introduction
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
01:24Chronic Pancreatitis I: Introduction
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
01:30Acute Pancreatitis II: Clinical Manifestations and Management
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...