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Microfabricated cylindrical multielectrodes for neural stimulation.

Sean Snow1, Stephen C Jacobsen, David L Wells

  • 1Department of Bioengineering, University of Utah, Salt Lake City 84112, USA. s.snow@m.cc.utah.edu

IEEE Transactions on Bio-Medical Engineering
|February 21, 2006
PubMed
Summary

New cylindrical multielectrodes show promise for functional electrical stimulation of the spinal cord. These electrodes may help ameliorate spinal cord injury effects by enabling precise neural stimulation.

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Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Materials Science

Background:

  • Spinal cord injuries (SCIs) can lead to significant motor and sensory deficits.
  • Functional electrical stimulation (FES) of the spinal cord is a promising therapeutic approach for SCI.
  • Current electrode technology may limit the efficacy and safety of FES.

Purpose of the Study:

  • To develop and evaluate a novel cylindrical multielectrode for spinal cord stimulation.
  • To assess the mechanical properties, electrical impedance, and charge delivery capacity of the new electrode design.

Main Methods:

  • Fabrication of cylindrical multielectrodes with four distinct tip shapes.
  • In vitro testing to determine peak insertion force for different tip shapes.
  • Monitoring of electrode-tissue interface impedance post-insertion and during stimulation.

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  • Evaluation of charge delivery capacity at safe and damaging charge densities.

    • Main Results:

    • Specific tip shapes demonstrated reduced peak insertion force, potentially minimizing tissue damage during implantation.
    • Electrode impedance remained stable after insertion and repetitive stimulation.
    • The electrodes exhibited adequate charge delivery capacity within safe limits.

    Conclusions:

    • The developed cylindrical multielectrodes are suitable for in vitro evaluation.
    • This electrode design holds potential for effective and safe neural stimulation in the ventral horn of the spinal cord.
    • Further research may lead to improved FES-based therapies for spinal cord injuries.