Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chaotic desynchronization of multistrain diseases.

Ira B Schwartz1, Leah B Shaw, Derek A T Cummings

  • 1U.S. Naval Research Laboratory, Code 6792, Nonlinear Systems Dynamics Section, Plasma Physics Division, Washington, DC 20375, USA.

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|February 21, 2006
PubMed
Summary

Multistrain diseases, like dengue hemorrhagic fever, can become chaotic due to antibody-dependent enhancement (ADE). Increased ADE causes outbreaks of different serotypes to desynchronize, though some groupings remain synchronized.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of Seasonal Births and Predation on Disease Spread.

Bulletin of mathematical biology·2026
Same author

Long-term antibody dynamics challenge the paradigm of lifelong homotypic immunity to dengue virus.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Epidemiological impacts of nonpharmaceutical interventions are modulated by immunity exposure trade offs.

Communications medicine·2026
Same author

Impact of Removing the Universal Hepatitis B Birth-Dose Vaccination in the US.

JAMA pediatrics·2026
Same author

Addressing the elephant in the room: Proceedings of the third annual Dengue Endgame Summit.

PLoS neglected tropical diseases·2026
Same author

Metagenomic surveillance reveals off-season circulation of respiratory viruses during the COVID-19 pandemic in Salvador, Brazil.

New microbes and new infections·2026

Area of Science:

  • Epidemiology
  • Mathematical modeling
  • Immunology

Background:

  • Multistrain diseases involve multiple serotypes that can interact.
  • Antibody-dependent enhancement (ADE) can worsen illness when infected with a second serotype.
  • Dengue hemorrhagic fever outbreaks show asynchronous serotype patterns.

Purpose of the Study:

  • To investigate the impact of ADE on the synchronization of multistrain disease outbreaks.
  • To model both autonomous and seasonally driven outbreaks with ADE.

Main Methods:

  • A mathematical model incorporating ADE was developed.
  • The model simulated outbreaks of multiple serotypes.
  • Analysis focused on the synchronization of infective numbers under varying ADE levels.

Related Experiment Videos

Main Results:

  • Low ADE levels led to synchronized outbreaks across serotypes.
  • Above a critical ADE threshold, the system exhibited chaotic behavior, desynchronizing serotype outbreaks.
  • Specific groupings of primary and secondary infectives maintained synchronization even in the chaotic regime.

Conclusions:

  • ADE significantly influences the synchronization dynamics of multistrain disease outbreaks.
  • The transition from synchronized to chaotic, desynchronized outbreaks is dependent on the level of ADE.
  • Understanding these dynamics is crucial for predicting and managing multistrain disease epidemics.