Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Telomere length in small-for-gestational-age babies.

A Akkad1, R Hastings, J C Konje

  • 1Fetal Growth and Development Research Group, Reproductive Science Section, Department of Cancer Studies and Molecular Medicine, Univerity of Leicester, Leicester, UK.

BJOG : an International Journal of Obstetrics and Gynaecology
|February 21, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

46th Medical Maghrebian Congress. November 9-10, 2018. Tunis.

La Tunisie medicale·2019
Same author

Gender differences in final year medical students' experience of teaching of intimate examinations: a questionnaire study.

BJOG : an international journal of obstetrics and gynaecology·2008
Same author

Women's accounts of consenting to surgery: is consent a quality problem?

Quality & safety in health care·2004
Same author

Intrapartum care for women on full anticoagulation.

International journal of obstetric anesthesia·2004
Same author

To transfuse or not to transfuse: iatrogenic compromise of women's reproductive careers.

Hospital medicine (London, England : 1998)·2001
Same author

Changes in serum vascular endothelial growth factor following initiation of estrogen replacement after hysterectomy and oophorectomy.

Acta obstetricia et gynecologica Scandinavica·2001

Small-for-gestational-age newborns do not have shorter telomeres than appropriately grown infants. Intrauterine growth restriction is not linked to increased telomere shortening in newborns.

Area of Science:

  • Genetics and Molecular Biology
  • Perinatology
  • Cardiovascular Health

Background:

  • Shortened telomeres in adults are linked to cardiovascular disease.
  • Telomere length is a biomarker for cellular aging and health outcomes.

Purpose of the Study:

  • To investigate if small-for-gestational-age (SGA) newborns exhibit shorter telomeres compared to controls.
  • To explore the relationship between intrauterine growth and telomere length at birth.

Main Methods:

  • Prospective cohort study involving 72 mother-newborn pairs.
  • Measurement of maternal and cord blood telomere length using Southern blot analysis.
  • Comparison of telomere lengths between SGA infants (≤3rd percentile) and appropriate-for-gestational-age controls (>10th percentile).

Related Experiment Videos

Main Results:

  • Maternal and newborn telomere lengths were significantly correlated (r2 = 0.25, P < 0.0001).
  • No significant difference in mean telomere length was observed between SGA newborns (10.33 ± 1.3 kb) and control newborns (10.36 ± 1.5 kb).
  • Maternal telomere lengths were also similar between the SGA (8.29 ± 1.0 kb) and control (8.41 ± 0.9 kb) groups.

Conclusions:

  • Impaired fetal growth associated with SGA status does not appear to result in accelerated telomere shortening at birth.
  • Findings suggest that intrauterine factors influencing fetal growth may not directly impact telomere length in newborns.