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Gut motor function: immunological control in enteric infection and inflammation.

W I Khan¹, S M Collins

¹Intestinal Diseases Research Program, Division of Gastroenterology, Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5 Canada. khanwal@mcmaster.ca

Clinical and Experimental Immunology

|February 21, 2006

Summary

Immune responses, specifically T helper 2 type, critically alter intestinal muscle function during parasitic infection. Modulating these immune responses may offer new treatments for gastrointestinal motility disorders like irritable bowel syndrome (IBS).

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Area of Science:

Gastroenterology
Immunology
Neurogastroenterology

Background:

Gastrointestinal (GI) motility disorders are common, often triggered by luminal factors.
The mechanisms by which mucosal injury impacts gut motor function remain unclear.
Immune cell activation is implicated in altered gut motor-sensory function.

Purpose of the Study:

To review the interface between the immune and motor systems in host resistance during enteric infection.
To elucidate the role of T helper 2 immune responses in infection-induced changes in intestinal muscle function.
To explore the potential clinical relevance of modulating immune responses for GI motility disorders.

Main Methods:

Review of studies utilizing a murine model of enteric nematode parasite infection.

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Analysis of the T helper 2 immune response during infection.

Investigation of the association between immune-mediated muscle function alterations and host defense.

Main Results:

Infection-induced T helper 2 immune responses are critical for altering intestinal muscle function.
These immune-mediated muscle function changes are linked to effective host defense against parasites.
Manipulation of the host immune response can modulate gut muscle function.

Conclusions:

The T helper 2 immune response plays a key role in regulating gut motor function during enteric infections.
Immune-mediated alterations in gut motility are crucial for host defense mechanisms.
Understanding this immune-motor axis provides insights into gastrointestinal motility disorders, including irritable bowel syndrome (IBS).