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Updated: Aug 18, 2026

An Orthotopic Bladder Cancer Model for Gene Delivery Studies
Published on: December 2, 2013
Human papillomavirus and carcinoma of the urinary bladder
S W Kerley1, D L Persons, J L Fishback
1Department of Pathology and Oncology, University of Kansas School of Medicine, Kansas City.
Abstract:
The human papillomaviruses have been strongly associated with anogenital cancers. Sporadic reports have linked papillomavirus infection to bladder neoplasms. We analyzed 27 normal and malignant bladder tissue samples for the presence of human papillomavirus by in situ DNA hybridization and the polymerase chain reaction. Only one invasive, keratinizing squamous cell carcinoma was found to contain human papillomavirus DNA. This occurred in a 61-yr-old female who was immunocompetent and had no previous evidence of papillomavirus-associated disease. This case represents the first invasive carcinoma of the bladder associated with papillomavirus infection.
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