Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tight junctions: molecular architecture and function.

Saima Aijaz1, Maria S Balda, Karl Matter

  • 1Division of Cell Biology, Institute of Ophthalmology, University College London, London, United Kingdom.

International Review of Cytology
|February 21, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ZONAB Regulates DNA Methylation, Mitochondrial Function, and Entry into Cell Senescence of Endothelial Cells.

Cells·2026
Same author

Enteropathogenic E. coli effector Map interacts with Rab13 and regulates the depletion of the tight junction proteins occludin and claudins via cathepsin B-mediated mechanisms.

Biology open·2025
Same author

The C-terminal proline-rich repeats of Enteropathogenic E. coli effector EspF are sufficient for the depletion of tight junction membrane proteins and interactions with early and recycling endosomes.

Gut pathogens·2024
Same author

ZO-1 Regulates Hippo-Independent YAP Activity and Cell Proliferation via a GEF-H1- and TBK1-Regulated Signalling Network.

Cells·2024
Same author

Correction: The Tight Junction Associated Signalling Proteins ZO-1 and ZONAB Regulate Retinal Pigment Epithelium Homeostasis in Mice.

PloS one·2023
Same author

Tight junctions.

Current biology : CB·2023
Same journal

Index.

International review of cytology·2020
Same journal

Index.

International review of cytology·2020
Same journal

Index.

International review of cytology·2020
Same journal

Index.

International review of cytology·2020
Same journal

Subject Index.

International review of cytology·2020
Same journal

Index.

International review of cytology·2020
See all related articles

Tight junctions form crucial epithelial barriers, regulating paracellular transport and cell signaling. Ongoing research reveals their complex protein network and mechanisms governing selective diffusion.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Physiology

Background:

  • Tight junctions are the apical-most structures of the epithelial junctional complex.
  • They are essential for forming and maintaining epithelial and endothelial barriers.
  • Tight junctions control the selective passage of ions and solutes via the paracellular pathway and restrict lipid diffusion.

Purpose of the Study:

  • To elucidate the molecular composition of tight junctions.
  • To understand the mechanisms underlying selective paracellular diffusion.
  • To identify the protein network at tight junctions and its role in signaling.

Main Methods:

  • Review of recent research on tight junction molecular composition.
  • Analysis of studies investigating paracellular transport mechanisms.

Related Experiment Videos

  • Identification of signaling components associated with tight junctions.

    • Main Results:

    • Significant insights into the molecular makeup of tight junctions have been gained.
    • Understanding of the mechanisms enabling selective paracellular diffusion is advancing.
    • A complex protein network, including cytoskeleton-linked adaptors, has been identified at tight junctions.

    Conclusions:

    • Tight junctions are key regulators of epithelial barrier function and paracellular transport.
    • The identified protein network at tight junctions plays a critical role in epithelial cell signaling, proliferation, differentiation, and polarization.