Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Protein expression pattern in experimental pneumococcal meningitis.

Matthias Klein1, Robert Paul, Barbara Angele

  • 1Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilian University, Marchioninistrasse 15, 81377 Munich, Germany.

Microbes and Infection
|February 21, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Untargeted metabolomics and proteomics reveals cocoa-mediated mitigation of valproic acid-induced dysregulation in a zebrafish model of autism: pilot study.

Metabolomics : Official journal of the Metabolomic Society·2026
Same author

Pain has limited predictive value for fractures following falls in older people: insight from a retrospective study.

BMC emergency medicine·2026
Same author

A shift towards a type I immune response in chronic atopic dermatitis favours an IL-15 dependent tissue resident memory cell niche.

Journal of dermatological science·2026
Same author

Type I interferon-activated NK cells control polycythemia vera in vivo.

Blood·2026
Same author

Macrophage IL-1β turns meningeal fibroblasts into inflammatory amplifiers in pneumococcal infection.

Frontiers in immunology·2026
Same author

REAMINAS-A Retrospective Study Evaluating the Completeness of the Emergency Department's Admission Medication and Its Influence on Discharge Medication.

Journal of clinical medicine·2026
Same journal

The extent of monocytic myeloid suppressor cells induction determines the host immune response during Mycobacterium avium infection.

Microbes and infection·2025
Same journal

Culture-attenuated pathogenic Leptospira lose the ability to survive complement lytic activity due to decreased C4BP uptake.

Microbes and infection·2025
Same journal

Exploring the link between genetically predicted plasma cathepsins and COVID-19: A mendelian randomization study of susceptibility and severity.

Microbes and infection·2025
Same journal

Laboratory parameters and serum tube agglutination test as markers for brucellosis treatment response.

Microbes and infection·2025
Same journal

Corrigendum to "Lactococcus lactis and Bifidobacterium longum attenuate Clostridioides difficile- or Clostridium symbiosum-induced colitis and depression/anxiety-like behavior in male mice" [Microb Infect 27(7) (2025) 105560].

Microbes and infection·2025
Same journal

Disrupted Microbiome-Metabolome networks underlie gut barrier and immune imbalance in severe fever with thrombocytopenia syndrome.

Microbes and infection·2025
See all related articles

This study reveals novel protein expressions in experimental pneumococcal meningitis using protein arrays. New factors identified may play crucial roles in disease progression and treatment strategies.

Area of Science:

  • Neuroscience
  • Immunology
  • Microbiology

Background:

  • Pneumococcal meningitis is a severe infection with significant neurological consequences.
  • Understanding the host's inflammatory response is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate cytokine and protein expression patterns in experimental pneumococcal meningitis.
  • To identify novel proteins involved in the acute and later stages of the disease.

Main Methods:

  • Intracisternal infection of mice with Streptococcus pneumoniae.
  • Ceftriaxone treatment initiated 24 hours post-infection.
  • Protein array analysis of mouse brain tissue at various time points.
  • ELISA validation for selected proteins (CXCL16, IGFBP3).

Related Experiment Videos

Main Results:

  • Marked elevation of known meningitis-relevant cytokines (IL-1beta, IL-6, KC, MIP-2, MCP-1/CCL2) in infected mice.
  • Identification of novel proteins during acute infection: XCL-1, CCL9, CCL12, CXCL10, CXCL16, IGFBP3.
  • Upregulation of T-cell related proteins (CCL1, CXCL4, CXCL13) and IL-4 during later stages.
  • ELISA confirmed protein array findings for CXCL16 and IGFBP3.

Conclusions:

  • Protein array technology significantly expands the understanding of protein expression in pneumococcal meningitis.
  • Several newly identified proteins may represent novel therapeutic targets or biomarkers for pneumococcal meningitis.