Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Circulating tumor cells: the 'leukemic phase' of solid cancers.

Simone Mocellin1, Ulrich Keilholz, Carlo Riccardo Rossi

  • 1Department of Oncological and Surgical Sciences, University of Padova, via Giustiniani 2, 35128 Padova, Italy. mocellins@hotmail.com

Trends in Molecular Medicine
|February 21, 2006
PubMed
Summary

Circulating tumor cells (CTCs) are found in cancer patients, but their role in metastasis and clinical significance are debated. Further research into CTC biology may personalize cancer therapy and improve drug development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diabetes and melanoma: Impact on prognosis and healthcare costs.

Journal of the European Academy of Dermatology and Venereology : JEADV·2026
Same author

Impact of comorbidities on survival in melanoma patients.

BMC cancer·2025
Same author

Healthcare costs of cutaneous melanoma according to comorbidity patterns: a population-based study from the Regional Cancer Registry of the Veneto Region.

Frontiers in public health·2025
Same author

Excision margins and prognosis in cutaneous melanoma: retrospective population-based cohort study.

BJS open·2025
Same author

A real-world direct cost associated with a 4-year postdiagnosis follow-up in a population-based cohort of patients with melanoma by clinical-pathological characteristics.

Melanoma research·2025
Same author

Completion of nodal dissection in cutaneous melanoma with metastatic sentinel nodes: Prognostic impact in a population-based cohort study.

World journal of surgical oncology·2025

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Malignant cells circulate in the bloodstream of patients with solid tumors.
  • The biological significance and clinical relevance of circulating tumor cells (CTCs) detection remain debated.
  • Conflicting results may stem from technical issues, discontinuous shedding, genomic instability, and metastatic inefficiency.

Purpose of the Study:

  • To review recent findings on CTC biology.
  • To discuss prospects for identifying and characterizing the CTC subset responsible for metastasis.
  • To highlight the potential of CTCs in cancer management.

Main Methods:

  • Review of recent scientific literature and clinical findings.
  • Discussion of technological advances in CTC detection and characterization.

Related Experiment Videos

  • Analysis of CTC biology and its role in metastasis.

    • Main Results:

    • Technological advances are enabling deeper investigation into CTC biology.
    • Recent clinical findings are prompting further research.
    • Identification of a specific CTC subset could be key to understanding metastasis.

    Conclusions:

    • Further understanding of CTC biology is crucial.
    • Molecular characterization of metastasis-driving CTCs holds significant promise.
    • CTCs can serve as a tool for prognosis, drug development, and personalized cancer therapy.